Comethylation of p16 and MGMT genes in colorectal carcinoma: Correlation with clinicopathological features and prognostic value

AIM: To investigate the significance of p16 and O(6)-methylguanine-DNA methyltransferase (MGMT) genes promoter hypermethylation and K-ras mutations on colorectal tumorigenesis and progression. METHODS: p16 and MGMT methylation status was examined on 47 tumor samples, and K-ras mutational status was...

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Detalhes bibliográficos
Main Authors: Krtolica, Koviljka, Krajnovic, Milena, Usaj-Knezevic, Slavica, Babic, Dragan, Jovanovic, Dusan, Dimitrijevic, Bogomir
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Co., Limited 2007
Assuntos:
Colorectal Cancer
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4146992/
https://ncbi.nlm.nih.gov/pubmed/17451198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v13.i8.1187
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