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Allopurinol reduces levels of urate and dopamine but not dopaminergic neurons in a dual pesticide model of Parkinson’s disease

Robust epidemiological data link higher levels of the antioxidant urate to a reduced risk of developing Parkinson’s disease (PD) and to a slower rate of its progression. Allopurinol, an inhibitor of xanthine oxidoreductase (XOR), blocks the oxidation of xanthine to urate. The present study sought to...

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Sonraí Bibleagrafaíochta
Main Authors: Kachroo, Anil, Schwarzschild, Michael A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4146456/
https://ncbi.nlm.nih.gov/pubmed/24680743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2014.03.031
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