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Mirk/dyrk1B kinase is upregulated following inhibition of mTOR
The PI3K/PTEN/Akt/mTOR/p70S6K pathway is one of the most frequently deregulated signaling pathways in solid tumors and has a functional role in drug resistance. However, targeting this pathway leads to compensatory activation of several mediators of cell survival. Expression of the reactive oxygen s...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4146409/ https://ncbi.nlm.nih.gov/pubmed/24590896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu058 |
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