A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis

Hypoxia-inducible factor 1 (HIF-1) attenuates amyloid-beta protein neurotoxicity and decreases apoptosis induced by oxidative stress or hypoxia in cortical neurons. In this study, we constructed a recombinant adeno-associated virus (rAAV) vector expressing the human HIF-1α gene (rAAV-HIF-1α), and te...

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Bibliografske podrobnosti
Main Authors: Chai, Xiqing, Kong, Weina, Liu, Lingyun, Yu, Wenguo, Zhang, Zhenqing, Sun, Yimin
Format: Artigo
Jezik:Inglês
Izdano: Medknow Publications & Media Pvt Ltd 2014
Teme:
Research and Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4146100/
https://ncbi.nlm.nih.gov/pubmed/25206774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/1673-5374.135317
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