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A poly(ethylene) glycolylated peptide for ocular delivery compacts DNA into nanoparticles for gene delivery to post-mitotic tissues in vivo

BACKGROUND: We have previously shown that a novel synthetic peptide for ocular delivery (POD) can efficiently compact DNA and deliver it to cells in vitro. This observation prompted us to develop use of POD as a nonviral vector in vivo. METHODS: POD peptide was modified using poly(ethylene) glycol (...

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Detalhes bibliográficos
Main Authors: Read, Sarah Parker, Cashman, Siobhan M., Kumar-Singh, Rajendra
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145735/
https://ncbi.nlm.nih.gov/pubmed/19937991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.1415
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