MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1

BACKGROUND: The IFN-α-inducible restriction factor MxB blocks HIV-1 infection after reverse transcription but prior to integration. Genetic evidence suggested that capsid is the viral determinant for restriction by MxB. This work explores the ability of MxB to bind to the HIV-1 core, and the role of...

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Autors principals: Fricke, Thomas, White, Tommy E, Schulte, Bianca, de Souza Aranha Vieira, Daniel A, Dharan, Adarsh, Campbell, Edward M, Brandariz-Nuñez, Alberto, Diaz-Griffero, Felipe
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145229/
https://ncbi.nlm.nih.gov/pubmed/25123063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-014-0068-x
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