MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1

BACKGROUND: The IFN-α-inducible restriction factor MxB blocks HIV-1 infection after reverse transcription but prior to integration. Genetic evidence suggested that capsid is the viral determinant for restriction by MxB. This work explores the ability of MxB to bind to the HIV-1 core, and the role of...

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Detalhes bibliográficos
Main Authors: Fricke, Thomas, White, Tommy E, Schulte, Bianca, de Souza Aranha Vieira, Daniel A, Dharan, Adarsh, Campbell, Edward M, Brandariz-Nuñez, Alberto, Diaz-Griffero, Felipe
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145229/
https://ncbi.nlm.nih.gov/pubmed/25123063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-014-0068-x
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