Clinical evaluation of the efficacy of methylnaltrexone in resolving constipation induced by different opioid subtypes combined with laboratory analysis of immunomodulatory and antiangiogenic effects of methylnaltrexone

BACKGROUND: Opioid-induced constipation (OIC) is one of the major symptoms in palliative care with a prevalence of 30-50%. Methylnaltrexone for the treatment of OIC is significantly more effective than placebo, but only in about fifty percent of the patients regardless of dose increase. Dose increas...

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Autori principali: Neefjes, Elisabeth CW, van der Vorst, Maurice JDL, Boddaert, Manon SA, Zuurmond, Wouter WA, van der Vliet, Hans J, Beeker, Aart, van den Berg, Hendrik P, van Groeningen, Cornelis J, Vrijaldenhoven, Suzan, Verheul, Henk MW
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Study Protocol
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145161/
https://ncbi.nlm.nih.gov/pubmed/25165428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-684X-13-42
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