Clinical evaluation of the efficacy of methylnaltrexone in resolving constipation induced by different opioid subtypes combined with laboratory analysis of immunomodulatory and antiangiogenic effects of methylnaltrexone

BACKGROUND: Opioid-induced constipation (OIC) is one of the major symptoms in palliative care with a prevalence of 30-50%. Methylnaltrexone for the treatment of OIC is significantly more effective than placebo, but only in about fifty percent of the patients regardless of dose increase. Dose increas...

詳細記述

保存先:
書誌詳細
主要な著者: Neefjes, Elisabeth CW, van der Vorst, Maurice JDL, Boddaert, Manon SA, Zuurmond, Wouter WA, van der Vliet, Hans J, Beeker, Aart, van den Berg, Hendrik P, van Groeningen, Cornelis J, Vrijaldenhoven, Suzan, Verheul, Henk MW
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2014
主題:
Study Protocol
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145161/
https://ncbi.nlm.nih.gov/pubmed/25165428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-684X-13-42
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