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Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness
The gain of a selective advantage in cancer as well as the establishment of complex traits during evolution require multiple genetic alterations, but how these mutations accumulate over time is currently unclear. There is increasing evidence that a mutator phenotype perpetuates the development of ma...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4145046/ https://ncbi.nlm.nih.gov/pubmed/24615916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201300140 |
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