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Evolution of Pre-Existing versus Acquired Resistance to Platinum Drugs and PARP Inhibitors in BRCA-Associated Cancers
Platinum drugs and PARP inhibitors (“PARPis”) are considered to be effective in BRCA-associated cancers with impaired DNA repair. These agents cause stalled and collapsed replication forks and create double-strand breaks effectively in the absence of repair mechanisms, resulting in arrest of the cel...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4144917/ https://ncbi.nlm.nih.gov/pubmed/25158060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105724 |
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