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Do Breast Cancer Cell Lines Provide a Relevant Model of the Patient Tumor Methylome?

It is well documented that tumor cells undergo dramatic genetic and epigenetic changes during initial establishment as cell lines and in subsequent serial passaging, and that the resultant cell lines may have evolved significantly from the primary tumors from which they were derived. This has potent...

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Bibliografske podrobnosti
Main Authors: Cope, Leslie M., Fackler, Mary Jo, Lopez-Bujanda, Zoila, Wolff, Antonio C., Visvanathan, Kala, Gray, Joe W., Sukumar, Saraswati, Umbricht, Christopher B.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144876/
https://ncbi.nlm.nih.gov/pubmed/25157401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105545
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