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ZO-1 Knockout by TALEN-Mediated Gene Targeting in MDCK Cells: Involvement of ZO-1 in the Regulation of Cytoskeleton and Cell Shape

ZO-1, ZO-2 and ZO-3 are tight junction-associated scaffold proteins that bind to transmembrane proteins of tight junctions and the underlying cytoskeleton. ZO-1 is involved in the regulation of cytoskeletal organization, but its detailed molecular mechanism is less well understood. Gene knockout is...

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Hlavní autoři: Tokuda, Shinsaku, Higashi, Tomohito, Furuse, Mikio
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144852/
https://ncbi.nlm.nih.gov/pubmed/25157572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104994
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