Enzymatic Oxidation of Cholesterol: Properties and Functional Effects of Cholestenone in Cell Membranes

Bacterial cholesterol oxidase is commonly used as an experimental tool to reduce cellular cholesterol content. That the treatment also generates the poorly degradable metabolite 4-cholesten-3-one (cholestenone) has received less attention. Here, we investigated the membrane partitioning of cholesten...

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Detalhes bibliográficos
Main Authors: Neuvonen, Maarit, Manna, Moutusi, Mokkila, Sini, Javanainen, Matti, Rog, Tomasz, Liu, Zheng, Bittman, Robert, Vattulainen, Ilpo, Ikonen, Elina
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144813/
https://ncbi.nlm.nih.gov/pubmed/25157633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103743
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