In Vitro Generation of Neuromesodermal Progenitors Reveals Distinct Roles for Wnt Signalling in the Specification of Spinal Cord and Paraxial Mesoderm Identity

Cells of the spinal cord and somites arise from shared, dual-fated precursors, located towards the posterior of the elongating embryo. Here we show that these neuromesodermal progenitors (NMPs) can readily be generated in vitro from mouse and human pluripotent stem cells by activating Wnt and Fgf si...

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Hlavní autoři: Gouti, Mina, Tsakiridis, Anestis, Wymeersch, Filip J., Huang, Yali, Kleinjung, Jens, Wilson, Valerie, Briscoe, James
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144800/
https://ncbi.nlm.nih.gov/pubmed/25157815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001937
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