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K(+) channel gating: C-type inactivation is enhanced by calcium or lanthanum outside

Many voltage-gated K(+) channels exhibit C-type inactivation. This typically slow process has been hypothesized to result from dilation of the outer-most ring of the carbonyls in the selectivity filter, destroying this ring’s ability to bind K(+) with high affinity. We report here strong enhancement...

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Detalhes bibliográficos
Main Authors: Armstrong, Clay M., Hoshi, Toshinori
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144669/
https://ncbi.nlm.nih.gov/pubmed/25156116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201411223
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