TARGETING GLIOMA INITIATING CELLS IN GBM: ABTC-0904, A RANDOMIZED PHASE 0/II STUDY TARGETING THE SONIC HEDGEHOG-SIGNALING PATHWAY

BACKGROUND: New therapeutic approaches are urgently needed for recurrent GBM (rGBM). Recent studies suggest that GBM oncogenesis and recurrence are regulated by glioma initiating cells (GIC), a minority population of quiescent cells driven by embryonic signaling pathways and resistant to radiation a...

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Autors principals: Sloan, Andrew E., Nock, Charles J., Supko, Jeff, Ye, Xiaobo, Takebe, Naoko, Rich, Jeremy, Prados, Michael, Grossman, Stuart
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144630/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou209.17
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