RANDOMIZATION OF PATIENTS WITH GLIOBLASTOMA TO VACCINE SITE PRE-CONDITIONING WITH TETANUS-DIPHTHERIA TOXOID SYSTEMICALLY ENHANCES MIGRATION AND THERAPEUTIC EFFECT OF CYTOMEGALOVIRUS PP65-PULSED DENDRITIC CELL VACCINE IN A MIP-1α-DEPENDENT FASHION

BACKGROUND: Dendritic cell (DC) vaccine efficacy is limited by suboptimal migration to vaccine site-draining lymph nodes (VDLNs). In mice, vaccine site conditioning with inflammatory cytokines or mature DCs increases DC trafficking and the induction of antigen-specific T cells. We assessed the impac...

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Hauptverfasser: Sampson, John, Mitchell, Duane A., Batich, Kristen A., Snyder, David, Xie, Weihua, Reap, Elizabeth, Cui, Xiuyu, Sanchez-Perez, Luis, Archer, Gary E., Nair, Smita K., Gunn, Michael D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144612/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou208.63
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