BIOLOGICALLY-BASED THERAPEUTICS FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMAS

BACKGROUND: Diffuse intrinsic pontine gliomas (DIPGs) in children carry a dismal prognosis despite the use of aggressive multi-modality treatment. Recent results have identified a somatic mutation in the H3F3A gene, resulting in replacement of lysine 27 by methionine in its encoded histone H3.3 prot...

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Main Authors: Gupta, Nalin, Hashizume, Rintaro, Andor, Noemi, Zhang, Zhiguo, Petritsch, Claudia, Mueller, Sabine, James, C. David
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144557/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou208.13
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