ABERRANT SPLICING OF A BRAIN-ENRICHED ALTERNATIVE EXON ELIMINATES TUMOR SUPPRESSOR FUNCTION AND PROMOTES ONCOGENE FUNCTION DURING BRAIN TUMORIGENESIS

BACKGROUND: Tissue-specific alternative splicing is known to be critical to emergence of tissue identity during development, yet its role in malignant transformation is undefined. Tissue-specific splicing involves evolutionary-conserved, alternative exons, which represent only a minority of total al...

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Główni autorzy: Bredel, Markus, Ferrarese, Roberto, Harsh, Griffith R., Yadav, Ajay K., Bug, Eva, Maticzka, Daniel, Reichardt, Wilfried, Masilamani, Anie P., Dai, Fangping, Kim, Hyunsoo, Hadler, Michael, Scholtens, Denise M., Yu, Irene L.Y., Beck, Jürgen, Srinivasasainagendra, Vinodh, Costa, Fabrizio, Baxan, Nicoleta, Pfeifer, Dietmar, Elverfeldt, Dominik v., Backofen, Rolf, Weyerbrock, Astrid, Duarte, Christine W., He, Xiaolin, Prinz, Marco, Chandler, James P., Vogel, Hannes, Chakravarti, Arnab, Rich, Jeremy N., Carro, Maria S.
Format: Artigo
Język:Inglês
Wydane: Oxford University Press 2014
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Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144541/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou206.71
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