ABERRANT SPLICING OF A BRAIN-ENRICHED ALTERNATIVE EXON ELIMINATES TUMOR SUPPRESSOR FUNCTION AND PROMOTES ONCOGENE FUNCTION DURING BRAIN TUMORIGENESIS

BACKGROUND: Tissue-specific alternative splicing is known to be critical to emergence of tissue identity during development, yet its role in malignant transformation is undefined. Tissue-specific splicing involves evolutionary-conserved, alternative exons, which represent only a minority of total al...

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Main Authors: Bredel, Markus, Ferrarese, Roberto, Harsh, Griffith R., Yadav, Ajay K., Bug, Eva, Maticzka, Daniel, Reichardt, Wilfried, Masilamani, Anie P., Dai, Fangping, Kim, Hyunsoo, Hadler, Michael, Scholtens, Denise M., Yu, Irene L.Y., Beck, Jürgen, Srinivasasainagendra, Vinodh, Costa, Fabrizio, Baxan, Nicoleta, Pfeifer, Dietmar, Elverfeldt, Dominik v., Backofen, Rolf, Weyerbrock, Astrid, Duarte, Christine W., He, Xiaolin, Prinz, Marco, Chandler, James P., Vogel, Hannes, Chakravarti, Arnab, Rich, Jeremy N., Carro, Maria S.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144541/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou206.71
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