The Antiproliferative and Apoptotic Effects of Sirtinol, a Sirtuin Inhibitor on Human Lung Cancer Cells by Modulating Akt/β-Catenin-Foxo3A Axis

Sirtuins, NAD(+)-dependent deacetylases, could target both histones and nonhistone proteins in mammalian cells. Sirt1 is the major sirtuin and has been shown to involve various cellular processes, including antiapoptosis, cellular senescence. Sirt1 was reported to be overexpressed in many cancers, i...

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Main Authors: Fong, Yao, Lin, Yin-Chieh, Wu, Chang-Yi, Wang, Hui-Min David, Lin, Li-Li, Chou, Han Lin, Teng, Yen-Ni, Yuan, Shyng-Shiou, Chiu, Chien-Chih
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144300/
https://ncbi.nlm.nih.gov/pubmed/25184156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/937051
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