Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model

Tuberous sclerosis complex (TSC), caused by dominant mutations in either TSC1 or TSC2 tumour suppressor genes is characterized by the presence of brain malformations, the cortical tubers that are thought to contribute to the generation of pharmacoresistant epilepsy. Here we report that tuberless het...

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Glavni autori: Lozovaya, N., Gataullina, S., Tsintsadze, T., Tsintsadze, V., Pallesi-Pocachard, E., Minlebaev, M., Goriounova, N. A., Buhler, E., Watrin, F., Shityakov, S., Becker, A. J., Bordey, A., Milh, M., Scavarda, D., Bulteau, C., Dorfmuller, G., Delalande, O., Represa, A., Cardoso, C., Dulac, O., Ben-Ari, Y., Burnashev, N.
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2014
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143949/
https://ncbi.nlm.nih.gov/pubmed/25081057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5563
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