Lack of Neuroprotective Effect of Celastrol Under Conditions of Proteasome Inhibition by Lactacystin in In Vitro and In Vivo Studies: Implications for Parkinson’s Disease

A number of studies suggest that the ubiquitin–proteasome system (UPS) impairment may underlie neuronal death in Parkinson’s disease. Celastrol is a neuroprotective agent with anti-inflammatory and antioxidant properties. The aim of this study was to determine whether celastrol may exert neuroprotec...

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Hlavní autoři: Konieczny, Jolanta, Jantas, Danuta, Lenda, Tomasz, Domin, Helena, Czarnecka, Anna, Kuter, Katarzyna, Śmiałowska, Maria, Lasoń, Władysław, Lorenc-Koci, Elżbieta
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143605/
https://ncbi.nlm.nih.gov/pubmed/24842651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12640-014-9477-9
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