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Lack of Neuroprotective Effect of Celastrol Under Conditions of Proteasome Inhibition by Lactacystin in In Vitro and In Vivo Studies: Implications for Parkinson’s Disease
A number of studies suggest that the ubiquitin–proteasome system (UPS) impairment may underlie neuronal death in Parkinson’s disease. Celastrol is a neuroprotective agent with anti-inflammatory and antioxidant properties. The aim of this study was to determine whether celastrol may exert neuroprotec...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer US
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4143605/ https://ncbi.nlm.nih.gov/pubmed/24842651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12640-014-9477-9 |
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