Key tumor suppressor genes inactivated by “greater promoter” methylation and somatic mutations in head and neck cancer

Tumor suppressor genes (TSGs) are commonly inactivated by somatic mutation and/or promoter methylation; yet, recent high-throughput genomic studies have not identified key TSGs inactivated by both mechanisms. We pursued an integrated molecular analysis based on methylation binding domain sequencing...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Guerrero-Preston, Rafael, Michailidi, Christina, Marchionni, Luigi, Pickering, Curtis R, Frederick, Mitchell J, Myers, Jeffrey N, Yegnasubramanian, Srinivasan, Hadar, Tal, Noordhuis, Maartje G, Zizkova, Veronika, Fertig, Elana, Agrawal, Nishant, Westra, William, Koch, Wayne, Califano, Joseph, Velculescu, Victor E, Sidransky, David
פורמט: Artigo
שפה:Inglês
יצא לאור: Landes Bioscience 2014
נושאים:
Research Paper
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143405/
https://ncbi.nlm.nih.gov/pubmed/24786473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.29025
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