Key tumor suppressor genes inactivated by “greater promoter” methylation and somatic mutations in head and neck cancer

Tumor suppressor genes (TSGs) are commonly inactivated by somatic mutation and/or promoter methylation; yet, recent high-throughput genomic studies have not identified key TSGs inactivated by both mechanisms. We pursued an integrated molecular analysis based on methylation binding domain sequencing...

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Main Authors: Guerrero-Preston, Rafael, Michailidi, Christina, Marchionni, Luigi, Pickering, Curtis R, Frederick, Mitchell J, Myers, Jeffrey N, Yegnasubramanian, Srinivasan, Hadar, Tal, Noordhuis, Maartje G, Zizkova, Veronika, Fertig, Elana, Agrawal, Nishant, Westra, William, Koch, Wayne, Califano, Joseph, Velculescu, Victor E, Sidransky, David
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2014
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143405/
https://ncbi.nlm.nih.gov/pubmed/24786473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.29025
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