In Vivo Imaging of Tumor Physiological, Metabolic, and Redox Changes in Response to the Anti-Angiogenic Agent Sunitinib: Longitudinal Assessment to Identify Transient Vascular Renormalization

Aims: The tumor microenvironment is characterized by a highly reducing redox status, a low pH, and hypoxia. Anti-angiogenic therapies for solid tumors frequently function in two steps: the transient normalization of structurally and functionally aberrant tumor blood vessels with increased blood perf...

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Detalhes bibliográficos
Main Authors: Matsumoto, Shingo, Saito, Keita, Takakusagi, Yoichi, Matsuo, Masayuki, Munasinghe, Jeeva P., Morris, Herman D., Lizak, Martin J., Merkle, Hellmut, Yasukawa, Keiji, Devasahayam, Nallathamby, Suburamanian, Sankaran, Mitchell, James B., Krishna, Murali C.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Original Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142786/
https://ncbi.nlm.nih.gov/pubmed/24597714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5725
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