Development of hepatocellular adenomas and carcinomas in mice with liver-specific G6Pase-α deficiency

Glycogen storage disease type 1a (GSD-1a) is caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α), and is characterized by impaired glucose homeostasis and a high risk of developing hepatocellular adenomas (HCAs). A globally G6Pase-α-deficient (G6pc(−/−)) mouse model that shows pathological...

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Detalhes bibliográficos
Main Authors: Resaz, Roberta, Vanni, Cristina, Segalerba, Daniela, Sementa, Angela R., Mastracci, Luca, Grillo, Federica, Murgia, Daniele, Bosco, Maria Carla, Chou, Janice Y., Barbieri, Ottavia, Varesio, Luigi, Eva, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Limited 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142728/
https://ncbi.nlm.nih.gov/pubmed/25147298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.014878
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