Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo

The effect of acute inhibition of both mTORC1 and mTORC2 on metabolism is unknown. A single injection of the mTOR kinase inhibitor, AZD8055, induced a transient, yet marked increase in fat oxidation and insulin resistance in mice, whereas the mTORC1 inhibitor rapamycin had no effect. AZD8055, but no...

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Autors principals: Kleinert, Maximilian, Sylow, Lykke, Fazakerley, Daniel J., Krycer, James R., Thomas, Kristen C., Oxbøll, Anne-Julie, Jordy, Andreas B., Jensen, Thomas E., Yang, Guang, Schjerling, Peter, Kiens, Bente, James, David E., Ruegg, Markus A., Richter, Erik A.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142396/
https://ncbi.nlm.nih.gov/pubmed/25161886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.06.004
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