Two cystic fibrosis transmembrane conductance regulator mutations have different effects on both pulmonary phenotype and regulation of outwardly rectified chloride currents.

Cystic fibrosis (CF), a disorder of electrolyte transport manifest in the lungs, pancreas, sweat duct, and vas deferens, is caused by mutations in the CF transmembrane conductance regulator (CFTR). The CFTR protein has been shown to function as a cAMP-activated chloride channel and also regulates a...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Fulmer, S B, Schwiebert, E M, Morales, M M, Guggino, W B, Cutting, G R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41423/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7542778/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.15.6832
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