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The in vitro metabolism of phospho-sulindac amide, a novel potential anticancer agent
Phospho-sulindac amide (PSA) is a novel potential anti-cancer and anti-inflammatory agent. Here we report the metabolism of PSA in vitro. PSA was rapidly hydroxylated at its butane-phosphate moiety to form two di-hydroxyl-PSA and four mono-hydroxyl-PSA metabolites in mouse and human liver microsomes...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4142141/ https://ncbi.nlm.nih.gov/pubmed/25044307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.07.007 |
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