Modeling RAS phenotype in colorectal cancer uncovers novel molecular traits of RAS dependency and improves prediction of response to targeted agents in patients

PURPOSE: KRAS wild-type status is an imperfect predictor of sensitivity to anti-EGFR monoclonal antibodies in colorectal cancer (CRC), motivating efforts to identify novel molecular aberrations driving RAS. This study aimed to build a quantitative readout of RAS pathway activity to: (1) uncover mole...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Guinney, Justin, Ferté, Charles, Dry, Jonathan, McEwen, Robert, Manceau, Gilles, Kao, KJ, Chang, Kai-Ming, Bendtsen, Claus, Hudson, Kevin, Huang, Erich, Dougherty, Brian, Ducreux, Michel, Soria, Jean-Charles, Friend, Stephen, Derry, Jonathan, Laurent-Puig, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141655/
https://ncbi.nlm.nih.gov/pubmed/24170544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1943
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados