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Asparaginase allergies: it’s all in the genes
In this issue of Blood, Fernandez et al demonstrate that human leukocyte antigen (HLA) DRB1 alleles confer high-affinity binding to asparaginase epitopes, leading to higher frequency of allergic reactions.(1) The authors initially examined HLA data from European ancestry patients enrolled onto St. J...
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society of Hematology
2014
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4141504/ https://ncbi.nlm.nih.gov/pubmed/25147374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-585919 |
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