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Asparaginase allergies: it’s all in the genes

In this issue of Blood, Fernandez et al demonstrate that human leukocyte antigen (HLA) DRB1 alleles confer high-affinity binding to asparaginase epitopes, leading to higher frequency of allergic reactions.(1) The authors initially examined HLA data from European ancestry patients enrolled onto St. J...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awdur: Wetzler, Meir
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141504/
https://ncbi.nlm.nih.gov/pubmed/25147374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-585919
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