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Predicting responsiveness to sorafenib: can the determination of FGF3/FGF4 amplifications enrich for clinical benefit?

A small proportion of patients with advanced hepatocellular carcinoma harbor FGF3/4 gene amplifications in an 11q13 amplicon. A recent report suggests that the presence of this alteration might enrich for sensitivity to sorafenib. Further, there is growing evidence that interference with the FGF/FGF...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Harding, James J., Abou-Alfa, Ghassan K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: AME Publishing Company 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141298/
https://ncbi.nlm.nih.gov/pubmed/25202691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3978/j.issn.2304-3881.2014.07.03
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