mTOR inhibition increases cell viability via autophagy induction during endoplasmic reticulum stress – An experimental and modeling study

Unfolded or misfolded proteins in the endoplasmic reticulum (ER) trigger an adaptive ER stress response known as unfolded protein response (UPR). Depending on the severity of ER stress, either autophagy-controlled survival or apoptotic cell death can be induced. The molecular mechanisms by which UPR...

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Autores principales: Kapuy, Orsolya, Vinod, P.K., Bánhegyi, Gábor
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2014
Materias:
Research article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141208/
https://ncbi.nlm.nih.gov/pubmed/25161878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2014.07.006
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