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mTOR inhibition increases cell viability via autophagy induction during endoplasmic reticulum stress – An experimental and modeling study
Unfolded or misfolded proteins in the endoplasmic reticulum (ER) trigger an adaptive ER stress response known as unfolded protein response (UPR). Depending on the severity of ER stress, either autophagy-controlled survival or apoptotic cell death can be induced. The molecular mechanisms by which UPR...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4141208/ https://ncbi.nlm.nih.gov/pubmed/25161878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2014.07.006 |
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