Staphylococcal SplB Serine Protease Utilizes a Novel Molecular Mechanism of Activation

Staphylococcal SplB protease belongs to the chymotrypsin family. Chymotrypsin zymogen is activated by proteolytic processing at the N terminus, resulting in significant structural rearrangement at the active site. Here, we demonstrate that the molecular mechanism of SplB protease activation differs...

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Detalles Bibliográficos
Main Authors: Pustelny, Katarzyna, Zdzalik, Michal, Stach, Natalia, Stec-Niemczyk, Justyna, Cichon, Przemyslaw, Czarna, Anna, Popowicz, Grzegorz, Mak, Pawel, Drag, Marcin, Salvesen, Guy S., Wladyka, Benedykt, Potempa, Jan, Dubin, Adam, Dubin, Grzegorz
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140910/
https://ncbi.nlm.nih.gov/pubmed/24713703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.507616
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