Inhibition of Cellular Methyltransferases Promotes Endothelial Cell Activation by Suppressing Glutathione Peroxidase 1 Protein Expression

S-Adenosylhomocysteine (SAH) is a negative regulator of most methyltransferases and the precursor for the cardiovascular risk factor homocysteine. We have previously identified a link between the homocysteine-induced suppression of the selenoprotein glutathione peroxidase 1 (GPx-1) and endothelial d...

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Detalhes bibliográficos
Main Authors: Barroso, Madalena, Florindo, Cristina, Kalwa, Hermann, Silva, Zélia, Turanov, Anton A., Carlson, Bradley A., de Almeida, Isabel Tavares, Blom, Henk J., Gladyshev, Vadim N., Hatfield, Dolph L., Michel, Thomas, Castro, Rita, Loscalzo, Joseph, Handy, Diane E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140892/
https://ncbi.nlm.nih.gov/pubmed/24719327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.549782
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