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Improving the Serum Stability of Site-Specific Antibody Conjugates with Sulfone Linkers
[Image: see text] Current routes for synthesizing antibody–drug conjugates commonly rely on maleimide linkers to react with cysteine thiols. However, thioether exchange with metabolites and serum proteins can compromise conjugate stability and diminish in vivo efficacy. We report the application of...
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Chemical
Society
2014
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| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4140540/ https://ncbi.nlm.nih.gov/pubmed/25099687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc500276m |
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