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Improving the Serum Stability of Site-Specific Antibody Conjugates with Sulfone Linkers

[Image: see text] Current routes for synthesizing antibody–drug conjugates commonly rely on maleimide linkers to react with cysteine thiols. However, thioether exchange with metabolites and serum proteins can compromise conjugate stability and diminish in vivo efficacy. We report the application of...

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Bibliografske podrobnosti
Main Authors: Patterson, James T., Asano, Shigehiro, Li, Xiuling, Rader, Christoph, Barbas, Carlos F.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140540/
https://ncbi.nlm.nih.gov/pubmed/25099687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc500276m
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