Expression of an expanded CGG-repeat RNA in a single pair of primary sensory neurons impairs olfactory adaptation in Caenorhabditis elegans

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a severe neurodegenerative disorder that affects carriers of premutation CGG-repeat expansion alleles of the fragile X mental retardation 1 (FMR1) gene; current evidence supports a causal role of the expanded CGG repeat within the FMR1 mRNA in t...

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Autors principals: Juang, Bi-Tzen, Ludwig, Anna L., Benedetti, Kelli L., Gu, Chen, Collins, Kimberly, Morales, Christopher, Asundi, Aarati, Wittmann, Torsten, L'Etoile, Noelle, Hagerman, Paul J.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140470/
https://ncbi.nlm.nih.gov/pubmed/24821701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu210
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