Survival motor neuron protein deficiency impairs myotube formation by altering myogenic gene expression and focal adhesion dynamics

While spinal muscular atrophy (SMA) is characterized by motor neuron degeneration, it is unclear whether and how much survival motor neuron (SMN) protein deficiency in muscle contributes to the pathophysiology of the disease. There is increasing evidence from patients and SMA model organisms that SM...

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Autors principals: Bricceno, Katherine V., Martinez, Tara, Leikina, Evgenia, Duguez, Stephanie, Partridge, Terence A., Chernomordik, Leonid V., Fischbeck, Kenneth H., Sumner, Charlotte J., Burnett, Barrington G.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140458/
https://ncbi.nlm.nih.gov/pubmed/24760765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu189
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