Histone deacetylase inhibition suppresses myogenin-dependent atrogene activation in spinal muscular atrophy mice

Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease caused by mutations in the survival of motor neuron 1 (SMN1) gene and deficient expression of the ubiquitously expressed SMN protein. Pathologically, SMA is characterized by motor neuron loss and severe muscle atrophy. Dur...

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Hauptverfasser: Bricceno, Katherine V., Sampognaro, Paul J., Van Meerbeke, James P., Sumner, Charlotte J., Fischbeck, Kenneth H., Burnett, Barrington G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2012
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529584/
https://ncbi.nlm.nih.gov/pubmed/22798624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds286
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