Concerted Amidation of Activated Esters: Reaction Path and Origins of Selectivity in the Kinetic Resolution of Cyclic Amines via N-Heterocyclic Carbenes and Hydroxamic Acid Cocatalyzed Acyl Transfer

[Image: see text] The N-heterocyclic carbene and hydroxamic acid cocatalyzed kinetic resolution of cyclic amines generates enantioenriched amines and amides with selectivity factors up to 127. In this report, a quantum mechanical study of the reaction mechanism indicates that the selectivity-determi...

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Bibliografiske detaljer
Main Authors: Allen, Scott E., Hsieh, Sheng-Ying, Gutierrez, Osvaldo, Bode, Jeffrey W., Kozlowski, Marisa C.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140451/
https://ncbi.nlm.nih.gov/pubmed/25050843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja505784w
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