In vivo persistence, tumor localization and anti-tumor activity of CAR engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB)

Human T cells engineered to express a chimeric antigen receptor (CAR) specific for folate receptor-alpha (FRα) have shown robust anti-tumor activity against epithelial cancers in vitro but not in the clinic due to their inability to persist and home to tumor in vivo. In this study, CARs were constru...

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Hlavní autoři: Song, De-Gang, Ye, Qunrui, Carpenito, Carmine, Poussin, Mathilde, Wang, Li-Ping, Ji, Chunyan, Figini, Mariangela, June, Carl H., Coukos, George, Powell, Daniel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140173/
https://ncbi.nlm.nih.gov/pubmed/21546571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-0422
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