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RLIP76 regulates HIF-1 activity, VEGF expression and secretion in tumor cells, and secretome transactivation of endothelial cells

This study was undertaken to reveal the mechanisms by which RLIP76 regulates endothelial cell angiogenic responses. RLIP76 is an effector of the angiogenic modulator, R-Ras. RLIP76 is overexpressed in many tumors, required for tumor angiogenesis, and blockade of RLIP76 results in tumor regression in...

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Detalhes bibliográficos
Main Authors: Lee, Seunghyung, Goldfinger, Lawrence E.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139904/
https://ncbi.nlm.nih.gov/pubmed/24928198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-255711
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