RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes

R-Ras small GTPase enhances cell spreading and motility via RalBP1/RLIP76, an R-Ras effector that links GTP-R-Ras to activation of Arf6 and Rac1 GTPases. Here, we report that RLIP76 performs these functions by binding cytohesin-2/ARNO, an Arf GTPase guanine exchange factor, and connecting it to R-Ra...

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Publicado en:Biochem Biophys Res Commun
Main Authors: Wurtzel, Jeremy G.T., Lee, Seunghyung, Singhal, Sharad S., Awasthi, Sanjay, Ginsberg, Mark H., Goldfinger, Lawrence E.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644438/
https://ncbi.nlm.nih.gov/pubmed/26498519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2015.10.064
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