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Loss of estrogen-mediated immunoprotection underlies female gender bias in experimental Crohn’s-like ileitis
The incidence and severity of Crohn’s disease (CD) are increased in female patients. Using SAMP1/YitFc (SAMP) mice, a spontaneous model of chronic intestinal inflammation that displays histologic and pathogenic similarities to human CD, we investigated the potential mechanism(s) contributing to sex...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4139459/ https://ncbi.nlm.nih.gov/pubmed/24621993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2014.15 |
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