Loss of estrogen-mediated immunoprotection underlies female gender bias in experimental Crohn’s-like ileitis

The incidence and severity of Crohn’s disease (CD) are increased in female patients. Using SAMP1/YitFc (SAMP) mice, a spontaneous model of chronic intestinal inflammation that displays histologic and pathogenic similarities to human CD, we investigated the potential mechanism(s) contributing to sex...

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Main Authors: Goodman, Wendy A., Garg, Rekha R., Reuter, Brian K., Mattioli, Benedetta, Rissman, Emilie F., Pizarro, Theresa T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139459/
https://ncbi.nlm.nih.gov/pubmed/24621993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2014.15
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