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The adaptor molecule TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating interleukin-2 receptor signaling
The number of Foxp3(+) regulatory T (T(reg)) cells must be tightly controlled to efficiently suppress autoimmunity while not impairing normal immune responses. Here we show that the adapter molecule TRAF3 is intrinsically required for restraining lineage determination of thymic T(reg) cells. T cell-...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4139452/ https://ncbi.nlm.nih.gov/pubmed/25029551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2944 |
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