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The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development

Tumor necrosis factor receptor–associated factor 3 (TRAF3) is an adaptor protein that inhibits signaling by CD40 and by the receptor for B cell–activating factor (BAFF) and negatively regulates homeostatic B cell survival. Loss-of-function mutations in TRAF3 are associated with human B cell malignan...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Lin, Wai W., Yi, Zuoan, Stunz, Laura L., Maine, Christian J., Sherman, Linda A., Bishop, Gail A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720969/
https://ncbi.nlm.nih.gov/pubmed/26329582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa5157
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